Here you can find our latest papers of psilocybe enzyme structures and biochemical characterization
Characterization of the Gateway Decarboxylase for Psilocybin Biosynthesis
How the magic begins: The l-tryptophan decarboxylase PsiD initiates the biosynthesis of the psychotropic natural product psilocybin in Psilocybe mushrooms. Its in vitro biochemical characterization and in silico modeling of its structure identified a non-canonical serine protease triad for autocatalytic cleavage of the proenzyme. PsiD’s substrate flexibility makes it a versatile catalyst for biotechnological applications.