Here you can find our latest papers of psilocybe enzyme structures and biochemical characterization

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202200551

Characterization of the Gateway Decarboxylase for Psilocybin Biosynthesis

Tim Schäfer, Kristina Kramer, Dr. Sebastiaan Werten, Dr. Bernhard Rupp, Prof. Dr. Dirk Hoffmeister

First published: 03 November 2022

How the magic begins: The l-tryptophan decarboxylase PsiD initiates the biosynthesis of the psychotropic natural product psilocybin in Psilocybe mushrooms. Its in vitro biochemical characterization and in silico modeling of its structure identified a non-canonical serine protease triad for autocatalytic cleavage of the proenzyme. PsiD’s substrate flexibility makes it a versatile catalyst for biotechnological applications.