{"id":243,"date":"2024-11-13T18:59:49","date_gmt":"2024-11-13T18:59:49","guid":{"rendered":"https:\/\/ruppweb.org\/psilosophy\/?p=243"},"modified":"2024-11-13T19:03:07","modified_gmt":"2024-11-13T19:03:07","slug":"psik-phosphorylation-of-4-oh-tryptamine-to-norbaeocystin","status":"publish","type":"post","link":"https:\/\/ruppweb.org\/psilosophy\/?p=243","title":{"rendered":"PsiK: Phosphorylation of 4-OH-Tryptamine to Norbaeocystin – FEBS Letters"},"content":{"rendered":"\n

Substrate recognition by the 4-hydroxytryptamine kinase PsiK in psilocybin biosynthesis<\/h1>\n\n\n\n

Kai Rogge<\/a>, Tobias Johannes Wagner<\/a>, Dirk Hoffmeister<\/a>, Bernhard Rupp<\/a>, Sebastiaan Werten<\/a><\/p>\n\n\n\n

First published: 24 October 2024 https:\/\/doi.org\/10.1002\/1873-3468.15042<\/a><\/p>\n\n\n\n

Psilocybin, the natural hallucinogen from Psilocybe<\/em> (magic) mushrooms, is a highly promising drug candidate for the treatment of depression and several other mental health conditions. Biosynthesis of psilocybin from the amino acid l-tryptophan involves four strictly sequential modifications. The third of these, ATP-dependent phosphorylation of the intermediate 4-hydroxytryptamine, is catalysed by PsiK. Here we present a crystallographic analysis and a structure-based mutagenesis study of this kinase, providing insight into its mode of substrate recognition. The results of our work will support future bioengineering efforts aimed at generating variants of psilocybin with enhanced therapeutic properties.<\/p>\n\n\n\n

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Substrate recognition by the 4-hydroxytryptamine kinase PsiK in psilocybin biosynthesis Kai Rogge, Tobias Johannes Wagner, Dirk Hoffmeister, Bernhard Rupp, Sebastiaan Werten First published: 24 October 2024 https:\/\/doi.org\/10.1002\/1873-3468.15042 Psilocybin, the natural hallucinogen from Psilocybe (magic) mushrooms, is a highly promising drug candidate for the treatment of depression and several other mental health conditions. Biosynthesis of psilocybin from the amino acid […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-243","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/ruppweb.org\/psilosophy\/index.php?rest_route=\/wp\/v2\/posts\/243","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ruppweb.org\/psilosophy\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ruppweb.org\/psilosophy\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ruppweb.org\/psilosophy\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ruppweb.org\/psilosophy\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=243"}],"version-history":[{"count":2,"href":"https:\/\/ruppweb.org\/psilosophy\/index.php?rest_route=\/wp\/v2\/posts\/243\/revisions"}],"predecessor-version":[{"id":247,"href":"https:\/\/ruppweb.org\/psilosophy\/index.php?rest_route=\/wp\/v2\/posts\/243\/revisions\/247"}],"wp:attachment":[{"href":"https:\/\/ruppweb.org\/psilosophy\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=243"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ruppweb.org\/psilosophy\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=243"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ruppweb.org\/psilosophy\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=243"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}