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If you cannot see it – is the magic still there?

PsiD: The first step in the making of the Magic -ChemBioChem

PsiK: Phosphorylation of 4-OH-Tryptamine to Norbaeocystin – FEBS Letters

The Second Methylation in Psilocybin Biosynthesis – ChemBioChem

The creation of the Magic: PsiM – Nature Communications

Sunday, September 14, 2025

Psilosophy: the Science of Psilocybin Biosynthesis

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If you cannot see it – is the magic still there?

admin April 21, 2025April 21, 2025Leave a comment

Here you can find our latest papers of psilocybe enzyme structures and biochemical characterization If you cannot see it - is it still there? Lukas Leitner,a Jesse Hudspeth,b,a Sebastiaan Wertenc and Bernhard Ruppc* Journal of…

PsiD: The first step in the making of the Magic -ChemBioChem

admin November 13, 2024November 13, 2024Leave a comment

Characterization of the Gateway Decarboxylase for Psilocybin Biosynthesis Tim Schäfer, Kristina Kramer, Dr. Sebastiaan Werten, Dr. Bernhard Rupp, Prof. Dr. Dirk Hoffmeister First published: 03 November 2022 How the magic begins: The l-tryptophan decarboxylase PsiD initiates…

PsiK: Phosphorylation of 4-OH-Tryptamine to Norbaeocystin – FEBS Letters

admin November 13, 2024November 13, 2024Leave a comment

Substrate recognition by the 4-hydroxytryptamine kinase PsiK in psilocybin biosynthesis Kai Rogge, Tobias Johannes Wagner, Dirk Hoffmeister, Bernhard Rupp, Sebastiaan Werten First published: 24 October 2024 https://doi.org/10.1002/1873-3468.15042 Psilocybin, the natural hallucinogen from Psilocybe (magic) mushrooms, is a highly promising…

The Second Methylation in Psilocybin Biosynthesis – ChemBioChem

admin November 13, 2024November 13, 2024Leave a comment

The Second Methylation in Psilocybin Biosynthesis Is Enabled by a Hydrogen Bonding Network Extending into the Secondary Sphere Surrounding the Methyltransferase Active Site Jesse Hudspeth, Kai Rogge, Tobias Wagner, Maximilian Müll, Dirk Hoffmeister, Bernhard Rupp, Sebastiaan Werten First published: 16 October…

The creation of the Magic: PsiM – Nature Communications

admin March 30, 2024November 13, 2024Leave a comment

Here you can find our latest papers of psilocybe enzyme structures and biochemical characterization Methyl transfer in psilocybin biosynthesis Jesse Hudspeth, Kai Rogge, Sebastian Dörner, Maximilian Müll, Dirk Hoffmeister, Bernhard Rupp & Sebastiaan Werten  Nature…

Bernhard Rupp and Dirk Hoffmeister | Design & develop by AmpleThemes